Neutrals who appear as Bosses in video games. They can range from simple to exceptionally difficult, the least extreme being mini-bosses and the most extreme being super-bosses. Games also have "final bosses", who are usually the main antagonists.

Special Note: These Neutrals can also appear in movies, comic books, and animation series IF they also appear in video games, though if these characters make no appearances in video games, they cannot count. In addition, Neutrals in video games that don't have boss battles do not count.